The Prevalence, and Associated Factors of Depressive Disorder in Patients Received Chemotherapy at Siriraj Hospital

Abstract

ABSTRACT

Objectives: 1) To study the prevalence of depression in patients received chemotherapy at Siriraj Hospital. 2) To determine the sensitivity and specificity of the two-question screening for depression, Thai-version in patients received chemotherapy at Siriraj Hospital. 3) To study factors that correlate with depression in patients received chemotherapy at Siriraj Hospital.

Method: The study was a cross-sectional survey on patients received chemotherapy at Siriraj Hospital. Patient was given a two-question screening for depression, which was a self-rated questionnaire. Subjects with positive screening result were further interviewed by the Thai version of the Diagnostic Interview for Genetics Studies, (Th-DIGS), depression section to confirm diagnosis of major depressive disorder. Subjects with negative screening were randomly selected equal to the positive screening group and also further interviewed by the Th-DIGS, depression section. SPSS 18.0 was used to analyze the data. Sensitivity, specificity, positive predictive value, negative predictive value and prevalence were calculated.

Results: There were 300 patients participated in the study. Sensitivity of the Thai-version of two-question screening for depression was 95.5%, specificity was 72.7%, PPV was 63.6% and NPV was 97.0%. The prevalence by proxy of major depressive disorder in patients received chemotherapy at Siriraj Hospital was 17.03%. Breast cancer, previouss history of major depressive disorder, and receiving chemotherapy with concurrent radiation therapy were significant correlated as risk factors for major depressive disorder.

Conclusion: The prevalence of major depressive disorder in the patients received chemotherapy at Siriraj Hospital was 17.03%. The two-question screening for depression, Thai-version had a high sensitivity and specificity and considered as a good instrument for screening depression in patients received chemotherapy. Breast cancer, previouss history of major depressive disorder, and receiving chemotherapy with concurrent radiation therapy were significant correlated as risk factors for major depressive disorder.