Hepatitis B virus and pre-employment examination

Authors

  • Pattamaphon Chanklom Occupational health unit, Chonburi hospital

DOI:

https://doi.org/10.14456/dcj.2024.6

Keywords:

hepatitis B virus, pre-employment examination, applicant, job, factor

Abstract

Hepatitis B virus (HBV) is transmitted through bloodborne contact and sexual intercourse. Occupations that involve the exposure to blood, such as healthcare workers and emergency responders, are at a higher risk of HBV infection. However, despite these transmission routes, many workplaces asked job applicants for their HBsAg test results. This is a cross-sectional analytic study aimed to 1) determine the prevalence of HBsAg testing for employment application, 2) assess the prevalence of HBV infection, and 3) identify factors associated with prevalence of HBV infection. This study enrolled job applicants who underwent pre-employment examinations in Chonburi hospital between May 2019 and December 2022, comprising 8,022 cases. Data were collected from electronic medical records included the date of visit, sex, age, marital status, job applied for, and result of HBsAg. Descriptive statistics were utilized. Evaluation of factors related to the prevalence of HBV infection was done by simple and multiple logistic regression. The findings revealed that total of 1,872 or 23,3% requested HBsAg testing for employment application. Regarding job categories, HBsAg testing in food handlers, healthcare workers, service workers, and manufacturing workers were 52.5%, 46.2%, 16.6%, and 9.4%, respectively. The prevalence of HBV infection among the applicants was 1.9%. Factors significantly associated with HBV infection (p<0.05) were age 41-50 years (AOR=12.6; 95% CI: 1.6-102.6), age 51-60 years (AOR=12.7; 95% CI: 1.3-123.9) and married (AOR=2.25; 95% CI: 1.1-4.8). In conclusion, applicants were facing unnecessary HBsAg testing. Additionally, the prevalence of HBV infection among applicants was found to be low and not significantly associated with job categories. Consequently, employers should consider discontinuing the requirement for HBsAg results from job applicants.

References

Russo FP, Zanetto A, Pinto E, Battistella S, Penzo B, Burra P, et al. Hepatocellular Carcinoma in chronic viral hepatitis: Where Do We Stand? Int J Mol Sci. 2022;23(1):500.

McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatol. 2009;49(5 Suppl):45-55.

Pramoolsinsap C, Pukrittayakamee S, Desakorn V. Hepatitis B problem in Thailand. Southeast Asian J Trop Med Public Health. 1986;17(2):219-28.

Leroi C, Adam P, Khamduang W, Kawilapat S, Ngo-Giang-Huong N, Ongwandee S, et al. Prevalence of chronic hepatitis B virus infection in Thailand: A systematic review and meta-analysis. Int J Infect Dis. 2016;51:36-43.

Daengsaard E, Thammawijaya P, Sookrak N, Tongprong P, Chumpatha N, Leaungsomnap Y. Prevalence of chronic hepatitis B virus infection, sexual risk behaviors, and hepatitis B vaccination among heterosexual men at sexually transmitted infections clinic, Bangkok, Thailand. Dis Control J. 2019;45(1):1-13. (in Thai)

Ngamurulert S, Janwithayanuchit I, Chuwongwattana S, Louisirirotchanakul S, Auewarakul P. Prevalence of hepatitis B virus infection in healthy Thai people after Implementation of the expanded program on immunization. Songkla Med J. 2017;35(1):47-53. (in Thai)

Thunyavinichkul P, Kitisupornpun S, Pormme N, Wasusophaphol W, Sangsawang S, Arunthong S, et al. Prevalence of Chronic Hepatitis B and Hepatitis C virus infection in Nongpakrang Subdistrict, Chiang Mai Province. J Dep Med Serv. 2017;42(2):102-9. (in Thai)

Upala P, Apidechkul T, Tamornpark R, Chomchoei C, Yeemard F. Seroprevalence and factors associated with hepatitis B infection among the hill tribe adult population in Thailand: a cross-sectional study. BMC Infect Dis. 2020;20:494.

Kiire CF. Hepatitis B infection in sub-Saharan Africa. Vaccine. 1990;8:107-12.

Prüss-üstün A, Rapiti E, Hutin YJF. Sharps injuries: global burden of disease from sharps injuries to health-care workers [Internat]. Geneva. 2003 [cited 2023 May 23]. Available from: https://www.who.int/publications/i/item/sharps-injuries-assessing-the-burden-of-disease-from-sharps-injuries-to-health-care-workers-at-national-and-local-levels

Daka D, Hailemeskel G, Fenta DA. Prevalence of hepatitis B virus infection and associated factors among female sex workers using respondent-driven sampling in Hawassa City, Southern Ethiopia. BMC Microbiol. 2022;22(1):37.

Pappas SC. Hepatitis B and health care workers. Clin Liver Dis. 2021;25(4):859-74.

Amaral TdS, Alves CMdS, Rezende FR, Caetano KAA, Tipple AFV. Serological and vaccine evaluation for hepatitis B among community health workers. Rev Lat Am Enfermagem. 2023;31:e3765.

Spearman CW, Afihene M, Ally R, Apica B, Awuku Y, Cunha L, et al. Hepatitis B in sub-Saharan Africa: strategies to achieve the 2030 elimination targets. Lancet Gastroenterol. Hepatol. 2017;2(12):900-9.

Rozen P, Babes VT, Buliga I, Buzărnescu G. B viral hepatitis as a risk factor for clinical laboratory personnel. Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1976;21(1):23-7.

Rischitelli G, Harris J, McCauley L, Gershon R, Guidotti T. The risk of acquiring hepatitis B or C among public safety workers: A systematic review. Am J Prev Med. 2001;20(4):299-306.

Urbanus AT, van den Hoek A, Boonstra A, van Houdt R, de Bruijn LJ, Heijman T, et al. People with multiple tattoos and/or piercings are not at increased risk for HBV or HCV in The Netherlands. PLoS One. 2011;6(9):e24736.

Wu H, Yim C, Chan A, Ho M, Heathcote J. Sociocultural factors that potentially affect the institution of prevention and treatment strategies for prevention of hepatitis B in Chinese Canadians. Can J Gastroenterol. 2009;23(1):31-6.

Wai CT, Mak B, Chua W, Tan MH, Ng S, Cheok A, et al. Misperceptions among patients with chronic hepatitis B in Singapore. World J Gastroenterol. 2005;11(32):5002-5.

Behera MK, Nath P, Behera SK, Padhi PK, Singh A, Singh SP. Unemployment and illiteracy are predictors of hepatitis b virus-related stigma and discrimination. J Clin Exp Hepatol. 2022;12(3):767-73.

Freeland C, Farrell S, Kumar P, Kamischke M, Jackson M, Bodor S, et al. Common concerns, barriers to care, and the lived experience of individuals with hepatitis B: a qualitative study. BMC Public Health. 2021;21(1):1004.

Chan HLY, Wong GLH, Wong VWS, Wong MCS, Chan CYK, Singh S. Questionnaire survey on knowledge, attitudes, and behaviour towards viral hepatitis among the Hong Kong public. Hong Kong Med J. 2022;28(1):45-53.

Cotler SJ, Cotler S, Xie H, Luc BJ, Layden TJ, Wong SS. Characterizing hepatitis B stigma in Chinese immigrants. J Viral Hepat. 2012;19(2):147-52.

Jin D, Brener L, Treloar C. Hepatitis B-related stigma among Chinese immigrants living with hepatitis B virus in Australia: A qualitative study. Health Soc Care Community. 2022;30(6):e5602-11.

Huang J, Guan ML, Balch J, Wu E, Rao H, Lin A, et al. Survey of hepatitis B knowledge and stigma among chronically infected patients and uninfected persons in Beijing, China. Liver Int. 2016;36(11):1595-603.

Li G, Wang G, Hsu FC, Xu J, Pei X, Zhao B, et al. Effects of depression, anxiety, stigma, and disclosure on health-related quality of life among chronic hepatitis B patients in Dalian, China. Am J Trop Med Hyg. 2020;102(5):988-94.

Abou Rached A, Abou Kheir S, Saba J, Ammar W. Epidemiology of hepatitis B and hepatitis C in Lebanon. Arab J Gastroenterol. 2016;17(1):29-33.

Tu T, Block JM, Wang S, Cohen C, Douglas MW. The lived experience of chronic hepatitis B: A broader view of its impacts and why we need a cure. Viruses. 2020;12(5):515.

Mokaya J, McNaughton A, Burbridge L, Maponga T, O'Hara G, Andersson M, et al. A blind spot? Confronting the stigma of hepatitis B virus (HBV) infection-A systematic review. Wellcome Open Res. 2018;3:29.

Scambler G. Health-related stigma. Sociol Health Illn. 2009;31(3):441-55.

Yu L, Wang J, Zhu D, Leng A, Wangen KR. Hepatitis B-related knowledge and vaccination in association with discrimination against Hepatitis B in rural China. Hum Vaccin Immunother. 2016;12(1):70-6.

Na L, Na B. A revolutionary road: an analysis of persons living with hepatitis B in China. J Health Commun. 2013;18(1):71-91.

Wang P, Li J, Pan X, Wang L, Wu G. Investigation and analysis of hepatitis B disease cognition and discrimination. J Nurs Train. 2013;28(17):1570-2.

Han B, Yuan Q, Shi Y, Wei L, Hou J, Shang J, et al. The experience of discrimination of individuals living with chronic hepatitis B in four provinces of China. PLoS One. 2018;13(4):e0195455.

Mohamed R, Ng CJ, Tong WT, Abidin SZ, Wong LP, Low WY. Knowledge, attitudes and practices among people with chronic hepatitis B attending a hepatology clinic in Malaysia: A cross sectional study. BMC Public Health. 2012;12:601.

Charles Ampong A, Sarah ES, Florence N, Robert ACR. Chronic Hepatitis B stigma in Ghana: a qualitative study with patients and providers. BMJ Open. 2019;9(6):e025503.

Smith-Palmer J, Cerri K, Sbarigia U, Chan EKH, Pollock RF, Valentine WJ, et al. Impact of stigma on people living with chronic hepatitis B. Patient Relat Outcome Meas. 2020;11:95-107.

De Schryver A, Claesen B, Meheus A, van Sprundel M, François G. European survey of hepatitis B vaccination policies for healthcare workers. Eur J Public Health. 2011;21(3):338-43.

Rajamoorthy Y, Radam A, Taib NM, Rahim KA, Munusamy S, Wagner AL, et al. Willingness to pay for hepatitis B vaccination in Selangor, Malaysia: A cross-sectional household survey. PLoS One. 2019;14(4):e0215125.

World Health Organization. Global Progress Report on HIV, viral hepatitis and sexually transmitted infections, 2021 [Internet]. 2021 [cited 2023 May 22]. Available from: https://www.who.int/publications/i/item/9789240027077

Chunsuttiwat S, Biggs BA, Maynard J, Thamapalo S, Laoboripat S, Bovornsin S, et al. Integration of hepatitis B vaccination into the expanded programme on immunization in Chonburi and Chiangmai provinces, Thailand. Vaccine. 1997;15(6-7):769-74.

Chongsrisawat V, Yoocharoen P, Theamboonlers A, Tharmaphornpilas P, Warinsathien P, Sinlaparatsamee S, et al. Hepatitis B seroprevalence in Thailand: 12 years after hepatitis B vaccine integration into the national expanded programme on immunization. Trop Med Int Health. 2006;11(10):1496-502.

Liu M, Li L, Zhao J, Ungvari GS, Ng CH, Duan Z, et al. Gender differences in demographic and clinical characteristics in patients with HBV-related liver diseases in China. PeerJ. 2022;10:e13828.

Hongjaisee S, Khamduang W, Sripan P, Choyrum S, Thepbundit V, Ngo-Giang-Huong N, et al. Prevalence and factors associated with hepatitis B and D virus infections among migrant sex workers in Chiangmai, Thailand: A cross-sectional study in 2019. Int J Infect Dis. 2020;100:247-54.

Rugaatwa Ndibarema E, Olum R, Ayebare D, Kabakyenga J. Prevalence and factors associated with hepatitis B infection among outpatient adults in South-Western Uganda. Hepat Med. 2022;14:163-72.

Asif A, Ayub S, Komal A, Noor S, Jalal U. Prevalence of human immunodeficiency virus and Hepatitis (B & C) among drug users in a tertiary care public hospital. Pak J Med Sci. 2019;35(2):459-63.

Chen Q, Liu J, He Y, Yang L, Luo H, Wang Y, et al. Prevalence of HBsAg among reproductive age couples in Chongqing: A population-based, cross-sectional study. PLoS One. 2021;16(11):e0260028.

Luksamijarulkul P, Piroonamornpun P, Triamchaisri SK. Hepatitis B seromarkers, hepatitis C antibody, and risk behaviors in married couples, a bordered province of western Thailand: Hepatitis B seromarkers, hepatitis C antibody, and risk behaviors. Hepat Mon. 2011;11(4):273-7.

Maamor NH, Muhamad NA, Mohd Dali NS, Abdul Mutalip MH, Leman FN, Aris T, et al. Seroprevalence of hepatitis B among healthcare workers in Asia and Africa and its association with their knowledge and awareness: a systematic review and meta-analysis. Public Health Front. 2022;10:859350.

Kateera F, Walker TD, Mutesa L, Mutabazi V, Musabeyesu E, Mukabatsinda C, et al. Hepatitis B and C seroprevalence among health care workers in a tertiary hospital in Rwanda. Trans R Soc Trop. 2015;109(3):203-8.

Downloads

Published

2024-03-31

How to Cite

1.
Chanklom P. Hepatitis B virus and pre-employment examination. Dis Control J [Internet]. 2024 Mar. 31 [cited 2024 May 2];50(1):63-7. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/264432

Issue

Section

Original Article