The correlation of triglyceride glucose index (TyG index) and hemoglobin A1C (HbA1C) in patients with type 2 diabetes

Authors

  • Phornchai Anivatthira Department of Family Medicine, King Chulalongkorn Memorial Hospital

DOI:

https://doi.org/10.14456/dcj.2023.32

Keywords:

Triglyceride-Glucose Index (TyG index), Hemoglobin A1C, type 2 diabetes mellitus

Abstract

The purpose of this correlation analysis was to investigate the relationship between triglyceride- glucose index (TyG index) and hemoglobin A1c (HbA1c) in type 2 diabetic patients receiving treatment in the Department of Family Medicine, King Chulalongkorn Memorial Hospital. The samples were 387 people. The study was conducted between January and September 2021. Data were collected using questionnaires and health measurement tools. Data were analyzed using descriptive statistics and correlation was analyzed using Pearson correlation coefficient and Partial correlation coefficient. The results showed that the triglyceride-glucose index was positively correlated with the hemoglobin A1c (HbA1c), with statistical significance and Partial correlation coefficient r=0.447 (p<0.001). In addition, it was found that triglyceride-glucose index (TyG index) was moderately associated with hemoglobin A1c (HbA1c). As a result, the triglyceride-glucose index could be beneficial in predicting type 2 diabetes controls in healthcare settings where there is no capacity to test for HbA1c. As a predictive factor, this TyG index will need to be further developed for use in combination with other variables.

References

Cavan D, Fernandes JDR, Makaroff L, Ogurtsov K, Webber S. IDF Diabetes Atlas. 7th ed. Brussels, Belgium: International Diabetes Federation; 2015:1-297.

International Diabetes Federation. IDF Diabetes Atlas. 9th ed. Brussels, Belgium: International Diabetes Federation; 2019.

Ekplakorn W. Report of the 5th Thai Health Examination Survey 2014: Thai People’s Health Survey Office/Public Health System Research Institute. Bangkok: Mahidol University; 2016. (in Thai)

Division of Non-Communicable Diseases, Department of Disease Control, Ministry of Public Health (TH). 5-Year National NCD Prevention and Control Strategic Plan (2017-2021). Nonthaburi: Division of Non-Communicable Diseases; 2017. (in Thai)

The Diabetes Association of Thailand. Clinical Practice Guideline for Diabetes 2017. Bangkok: The Diabetes Association of Thailand; 2017. (in Thai)

Neelasri J, Tanaphuwanont O. Factors Associated with HbA1c Levels of Type 2 Diabetes Patients, Thayang Hospital, Phetchaburi Province, Thailand. Region 4-5 Medical Journal. 2020;39(4):715-28. (in Thai)

Alqahtani N, Khan WA, Alhumaidi MH, Ahmed YA. Use of Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus and Pre-diabetes and Role of Fasting Plasma Glucose, Oral Glucose Tolerance Test. Int J Prev Med. 2013;4(9):1025-9.

American Diabetes Association. Classification and Diagnosis of Diabetes. Diabetes Care. 2017;40(Suppl 1):S11-24.

International Diabetes Federation. Global guideline for type 2 diabetes. Belgium: International Diabetes Federation; 2012.

Gonzalez-Chavez A, Simental-Mendia LE, Elizondo-Argueta S. Elevated triglycerides/HDL -cholesterol ratio associated with insulin resistance. Cir Cir. 2011;79(2):126-31.

Ren X, Chen Z, Zheng S, Han T, Li Y, Liu W, et al. Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus. PLoS One. 2016;11(4)

BabicN,Valjevac A, Zaciragic A, AvdagicN,Zukic S, Hasic S. The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2. Med Arch. 2019;73(3):163-8.

Lee EY, Yang HK, Lee J, Kang B, Yang Y, Lee SH, et al. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis. 2016;15:155.

Hulley SB, Cummings SR, Browner WS, Grady D, Newman TB. Designing clinical research: an epidemiologic approach. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013. Appendix 6C, p. 79

Hameed EK. TyG index a promising biomarker for glycemic control in type 2 Diabetes Mellitus. Diabetes MetabSyndr. 2019;13(1):560-3.

American Diabetes Association. Standards of medical care in diabetes-2018. Diabetes Care. 2018;41(1):S57-9.

Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111-88.

Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. 2018 Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73(24):e285-350.

Dotevall A, Johansson S, Wilhelmsen L, Rosengren A. Increased levels of triglycerides, BMI and blood pressure and low physical activity increase the risk of diabetes in Swedish women. A prospective 18-year follow-up of the BEDA study. Diabet Med. 2004;21(6):615-22.

Miselli MA, Nora ED, Passaro A, Tomasi F, Zuliani G. Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: a longitudinal observational study. Cardiovasc Diabetol. 2014;13:135.

Zhang M, Wang B, Liu Y, Sun X, Luo X, Wang C, et al. Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study. Cardiovasc Diabetol. 2017;16(1):30.

Du T, Yuan G, Zhang M, Zhou X, Sun X, Yu X. Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance. Cardiovasc Diabetol. 2014;13:146.

Navarro-Gonzalez D, Sanchez-Inigo L, Pastrana-Delgado J, Fernandez-Montero A, Martinez JA. Triglyceride-glucose index (TyG index) in comparison with fasting plasma glucose improved diabetes prediction in patients with normal fasting glucose: The Vascular-Metabolic CUN cohort. Prev Med. 2016;86:99-105.

Moon S, Park JS, Ahn Y. The Cut-off Values of Triglycerides and Glucose Index. J Korean Med Sci. 2017;32:427-33

Fritz J, Bjorge T, Nagel G, Manjer J, Engeland A, Haggstrom C, et al. The triglyceride-glucose index as a measure of insulin resistance and risk of obesity-related cancers. Int J Epidemiol. 2020;49(1):193-204.

Park K, Ahn CW, Lee SB, Kang S, Nam JS, Lee BK, et al. Elevated TyG index Predicts Progression of Coronary Artery Calcification. Diabetes Care. 2019;42(8):1569-73.

Sanchez-Inigo L, Navarro-Gonzalez D, Fernandez-Montero A, Pastrana-Delgado J, Martinez JA. The TyG index may predict the development of cardiovascular events. Eur J Clin Invest. 2016;46(2):189-97.

Jin JL, Cao YX, Wu LG, You XD, Guo YL, Wu NQ, et al. Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease. J Thorac Dis. 2018;10(11):6137-46.

Chiu H, Tsai HJ, Huang JC, Wu PY, Hsu WH, Lee MY, et al. Associations between Triglyceride-Glucose Index and Micro- and Macro-angiopathies in Type 2 Diabetes Mellitus. Nutrients. 2020;12(2).

Downloads

Published

2023-06-29

How to Cite

1.
Anivatthira P. The correlation of triglyceride glucose index (TyG index) and hemoglobin A1C (HbA1C) in patients with type 2 diabetes . Dis Control J [Internet]. 2023 Jun. 29 [cited 2024 May 10];49(2):379-88. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/256578

Issue

Section

Original Article