Syphilis: resurgence

Authors

  • Sakchai Chaiyamahapurk Faculty of Medicine, Naresuan University
  • Rossaphorn Kittiyaowamarn Division of AIDS and Sexual Transmitted Diseases, Department of disease control

DOI:

https://doi.org/10.14456/dcj.2021.18

Keywords:

syphilis, diagnosis, treatment

Abstract

Syphilis incidence per 100,000 population in Thailand increased five times from 2.16 in year 2008 to 11.51 in year 2018.  Early diagnosis and treatment of syphilis reduce the transmissions, morbidity and mortality from syphilis and congenital syphilis. Diagnosis is by using medical history, signs and symptoms, epidemiological data, and serologic testing for syphilis infection. Penicillin is a drug of choice. Syphilis can be prevented and controlled by early diagnosis and treatment, diagnosis and treatment of sexual partners, screening in pregnant women, and high-risk groups such as men having sex with men (MSM), teenagers and commercial sex workers. Condom use is still the effective way in prevent sexually transmitted diseases. This article presents a knowledge review on diagnosis and treatment of syphilis which are essential part of syphilis prevention and control.

Downloads

Download data is not yet available.

References

James WD, Berger TG, Elston DM. Andrew's Diseases of the Skin. 12th ed. Philadelphia: Elsevier; 2016. p. 343-55.

World Health Organization. Report on global sexually transmitted infection surveillance. Geneva: Switzerland; 2018.

Syphilis epidemic. Department of Disease Control, Thailand. DDC watch 2019 June 6 [Internet]. [cited 2020 Mar 1]. Available from: https://ddc.moph.go.th/uploads/files/99940f1539ab5048b6afcf48e2e0a36c.pdf (in Thai)

Stary A, Stary G. Sexually transmitted infections. In: Bolognia JL, Schaffer JV, Cerroni L, editors. Dermatology. 3 th ed. Philadelphia: Elsevier; 2012. p. 1367-89.

Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines. MMWR. 2015;64:1-137.

Janier M, Hegyi V, Dupin N, Unemo M, Tiplica GS, Potocnik M, et al. 2014 European guideline on the management of syphilis. JEADV. 2014;28:1581-93.

World Health Organization. WHO Guidelines for the Treatment of Treponema pallidum (Syphilis). Geneva: Switzerland; 2018.

Ropper AH, Samuels MA, Klein JP, Prasad S. Adams and Victor's Principles of Neurology. 11th ed. New York: McGraw-Hill; 2019. p. 743-8.

Centers for Disease Control and Prevention. Syphilis testing algorithms using treponemal tests for initial screening--four laboratories, New York City, 2005-2006. MMWR. 2008;57:872.

Park IU, Fakile YF, Chow JM, Gustafson KJ, Jost H, Schapiroet JM, et al. Performance of treponemal tests for the diagnosis of syphilis. Clin Infect Dis. 2019;68:913-8.

Division of AIDS and Sexual Transmitted Disease, Division of Tuberculosis, Department of Disease Control. Guideline for treatment of sexually transmitted diseases 2015. Department of Disease Control (TH); 2015. (in Thai)

Dai T, Qu R, Liu J, Zhou P, Wang Q. Efficacy of Doxycycline in the Treatment of Syphilis. Antimicrob Agents Chemother. 2016;61(1):e01092-16.

O'Byrne P, MacPherson P. Syphilis. BMJ. 2019;365:41-59.

Hicks CB, Clement M. Syphilis: Screening and diagnostic testing. In: Marazzo J, Mitty J, ed. Up-to-date {database on the internet}. Watham (MA): Uptodate; 2020[Internet]. [cited 2020 Mar 1]. Available from: https://www.uptodate.com/contents/syphilis-screening-and-diagnostic-testing

Division of AIDS and Sexual Transmitted Disease, Division of Tuberculosis, Department of Disease Control. National guideline on the management for the elimination of congenital syphilis in Thailand, 2015. Nonthaburi: Department of Disease Control (TH); 2015. (in Thai)

Cantor A, Nelson HD, Daeges M, Pappas M. Screening for syphilis in nonpregnant adolescents and adults: systematic review to update the 2004 US Preventive ServicesTask Force recommendation. Evidence Synthesis No 136. Agency for Healthcare Research and Quality [Internet]. 2016 [cited 2000 Mar 1]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK368467/pdf/Bookshelf_NBK368467.pdf

Ishikane M, Arima Y, Itoda I, Yamagishi T, Takahashi T, Matsui T, et al. Case-control study of risk factors for incident syphilis infection among men who have sex with men in Tokyo, Japan. Western Pac surveill Response J. 2019;10:1-8.

Wilkinson AL, Scott N, Tidhar T, Luong P, El-Hayek C, Wilson DP, et al. Estimating the syphilis epidemic among gay, bisexual and other men who have sex with men in Australia following changes in HIV care and prevention. Sex Health. 2019;16:254-62

Downloads

Published

2021-06-27

How to Cite

1.
Chaiyamahapurk S, Kittiyaowamarn R. Syphilis: resurgence. Dis Control J [Internet]. 2021 Jun. 27 [cited 2024 Nov. 18];47(2):199-208. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/241898

Issue

Section

Review Article