Treatment success rate, Factors contributing to treatment success and predictors for forecasting the favorable outcome in tuberculosis patients under DOTS strategy in Tuberculosis clinic in Chian Yai Hospital, Nakhon Si Thammarat Province
DOI:
https://doi.org/10.14456/dcj.2020.25Keywords:
Tuberculosis, Treatment Success rate, DOTSAbstract
Tuberculosis (TB) treatment success rate remains a public health challenge in many developed and developing countries. This retrospective study aimed to determine the treatment success rate and investigate factors associated with treatment outcomes in tuberculosis patients by DOTS strategy in tuberculosis clinic, Chian Yai hospital. Three-year (2015 to 2017) TB records of TB clinic of the hospital were reviewed. A total of 266 registered TB patients with completed information were included. The chi–square and fisher’s exact test were used to test the association among independent variables and treatment outcomes. Unconditional logistic regression analysis was used to estimate the magnitude of associations and predict treatment outcomes among tuberculosis patients. The study results demonstrated that treatment success rate was 81.2%, and factors significantly associated with favorable treatment outcomes were patients with DOTS apply (aOR=3.9, 95%CI=1.5–10.1, p=0.005), and those without concomitant diseases or complications while on treatment (aOR=7.3, 95%CI=3.0–17.7, p0.001). Therefore, patients susceptible to treatment failure should be closely monitored and aggressively treated to increase the rate of clinical success.
References
Division of Tuberculosis, Ministry of Public Health. National tuberculosis control programme guideline, Thailand, 2008. 3rded. Bangkok: The agricultural co–operative federation of Thailand; 2008. (in Thai)
Division of Tuberculosis, Ministry of Public Health. Comprehensive guide to tuberculosis management in the national health security system. Bangkok: The agricultural co–operative federation of Thailand; 2008. (in Thai)
Bureau of Tuberculosis, Department of Disease Control, Ministry of Public Health. National tuberculosis control programme guideline, Thailand, 2018. Nonthaburi: Bureau of Tuberculosis; 2018. (in Thai)
World Health Organization. Global tuberculosis report 2017. Geneva: Switzerland: WHO; 2017.
Bureau of Tuberculosis, Department of Disease Control, Ministry of Public Health. Thailand operational plan to end TB 2017–2021. Nonthaburi: Bureau of Tuberculosis; 2018. (in Thai)
Bureau of Tuberculosis, Department of Disease Control, Ministry of Public Health. Report of tuberculosis program performance in Thailand, 2009–2015. Nonthaburi: Bureau of Tuberculosis; 2016. (in Thai)
Quality Center, Chian Yai Hospital. Annual government performance report, fiscal year 2017. Nakhon Si Thammarat: Quality Center, Chian Yai Hospital; 2018. (in Thai)
Wen Y, Zhang Z, Li X, Xia D, Ma J, Dong Y, et al. Treatment outcomes and factors affecting unsuccessful outcome among new pulmonary smear positive and negative tuberculosis patients in Aqing, China: a retrospective study. BMC Infectious Diseases 2018;18:104.doi.org/10.1186/s12879–018–3019–7.
Gebrezgabiher G, Romha G, Ejeta E, Asebe G, Zemene E, Ameni G. Treatment outcome of tuberculosis patients under directly observed treatment short course and factors affecting outcome in Southern Ethiopia: a five–year retrospective study. PLoS ONE 2016;11(2):e0150560.doi:10.1371/journal.pone.0150560.
Dobler CC, Korver S, Batbayar O, Oyuntsetseg S, Tsolmon B, Wright C, et al. Success of community–based directly observed anti–tuberculosis treatment in Mongolia. Int J Tuberc Lung Dis 2015;19:657–62.
Okanurak K, Kitayaporn D, Akarasewi P. Factors contributing to treatment success among tuberculosis patients: a prospective cohort study in Bangkok. Int J Tuberc Lung Dis 2008;12:1160–5.
Babalik A, Kilicaslan Z, Kiziltas S, Gencer S, Ongen G. A retrospective case–control study, factors affecting treatment outcomes for pulmonary tuberculosis in Istanbul, Turkey. Balkan Med J 2013;30:204–10.
Anuwatnonthakate A, Limsomboon P, Nateniyom S, Wattanaamornkiat W, Komsakorn S, Moolphate S, et al. Directly observed therapy and improved tuberculosis treatment outcomes in Thailand. PloS ONE 2008;3(8):e3089.
Manissero D, Hollo V, Huitric E, Kodmon C, Amato–Gauci A. Analysis of tuberculosis treatment outcomes in the European Union and European Economic Area: efforts needed towards optimal case management and control. Euro Surveill 2010;15(11):pii=19514.
Reechaipichitkul W, So–ngern A, Chaimanee P. Treatment outcomes of new and previously–treated smear positive pulmonary tuberculosis at Srinagarind hospital, a tertiary care center in Northeast Thailand. J Med Assoc Thai 2014;97:490–9.
Wongkalasin P. Factors affecting treatment outcome of new pulmonary tuberculosis patients in Pannanikhom district, Sakhon Nakhon province. Journal of Health System Research 2007;1:439–46.(in Thai)
Balian DR, Davtyan K, Balian A, Grigoryan A, Hayrapetyan A, & Davtyan H. Tuberculosis treatment and smoking, Armenia, 2014–2016. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases 2017;8:1–5.
Nik Nor Ronaidi NM, Mohd NS, Wan Mohammad Z, Sharina D, & Nik Rosmawati NH. Factors associated with unsuccessful treatment outcome of pulmonary tuberculosis in Kota Bharu, Kelantan. Malaysian Journal of Public Health Medicine 2011;11:6–15.
Bulabula ANH, Nelson JA, Musafiri EM, Machekano R, Sam–Agudu NA, Diacon AH, et al. Prevalence, predictors, and successful treatment outcomes of Xpert MTB/RIF–identified Rifampicin–resistant tuberculosis in Post–conflict Eastern Democratic Republic of the Congo, 2012–2017: a retrospective province–wide cohort study. CID 2019;69:1278–87.
Talay F, Kumbetli S, Altin S. Factors associated with treatment success for tuberculosis patients: a single center’s experience in Turkey. Jpn J Infect Dis 2008;61:25–30.
Getahun B, Ameni G, Medhin G, Biadgilign S. Treatment outcome of tuberculosis patients under directly observed treatment in Addis Ababa, Ethiopia. BRAZ J Infect Dis 2013;17:521–8.
Rattanasuwan P. Principle of tuberculosis control, experience 10 years. 3rded. Nakhon Si Thammarat: Medsai; 2005. (in Thai)
World Health Organization. Treatment of tuberculosis guidelines. 4th ed. WHO/HTM/TB/2009.420. Geneva, Switzerland: WHO; 2009.
Namukwaya E, Nakwagala FN, Mulekya F, Mayanja–Kizza H, Mugerwa R. Predictors of treatment failure among pulmonary tuberculosis patients in Mulago hospital, Uganda. Afr Health Sci 2011;11:105–11.
Tipaht P, Suggaravetsin P. Factors associated with success of treatment among new smear–positive pulmonary tuberculosis patients between urban and rural area in Chaiyaphum province, Thailand. Office of Disease Prevention and Control 5th Nakhon Ratchasima 2008;15:5–18. (in Thai)
Claxton AJ, Cramer J, Pierce C. A systematic review of associations between dose regimens and medication compliance. Clin Ther 2001;23:1296–310.
Jha UM, Satyanarayana S, Dewan PK, Chadha S, Wares F, Sahu S, et al. Risk factors for treatment default among re–treatment tuberculosis patients in India. PLoS ONE 2006;5:e8873.doi:10.1371/journal.pone.0008873.
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