The study of the efficacy of multipurpose solutions to inhibit bacteria on soft contact lens

Authors

  • ธีรภัทร ทองวิเศษสุข Faculty of Allied Health Sciences, Naresuan University
  • เบญญา สินปรุ Faculty of Allied Health Sciences, Naresuan University
  • ภัทรชนก หลำใจซื่อ Faculty of Allied Health Sciences, Naresuan University
  • นพดล จำรูญ Faculty of Allied Health Sciences, Naresuan University

DOI:

https://doi.org/10.14456/dcj.2018.37

Keywords:

multipurpose solutions, bacteria, soft contact lens

Abstract

A contact lens is the most commonly used medical device for visual correction. However, the incidence of contact lens contamination and contact lens-related microbial keratitis remain a health problem. Thus, various types of multipurpose solutions have been developed for cleaning a used contact lens. The aim of this study is to test the efficacy of three multipurpose solutions brands (A, B and C) in terms of their efficacy to inhibit the growth of Pseudomonas aeruginosa ATCC 25923 and Staphylococcus aureus ATCC 25923 contaminated on a soft contact lens. In this study, the solutions A and C, which contain the same ingredients (i.e. boric acid, polidronium chloride 0.001%, myristamidopropyl dimethylamine 0.0005%), and the solution B, which consists of boric acid, sodium borate, polyaminopropyl biguanide 0.00013%, polyquaternium 0.0001% were found to have demonstrated the optimum temperature and incubation time for inhibiting the growth of bacteria. A bacterial cell concentration of as 1.5X106 CFU/ml was selected to prepare a soft contact lens bacterial contamination model. All the three solutions could inhibit the growth of P. aeruginosa ATCC 25923 and S. aureus ATCC 25923 based on the indications on the medication information leaflet of each product. As a result, the solutions A, B and C could inhibit S. aureus from 2 hours to 28 days at 6±2˚C, 25±2˚C and 35±2˚C. Both A and C solutions could inhibit P. aeruginosa from 2 hours to 28 days at all temperatures studied. The solution B could inhibit P. Aeruginosa from 2 hours to 28 days at 25±2˚C but <24 hours at 6±2˚C and <4 hours at 35±2˚C, the colonies of P. aeruginosa were still found under these conditions. Findings from this study could be used as the guidelines for cleaning and storing a soft contact lens with multipurpose solutions to prevent microbial keratitis from a used contact

References

1. Eltis M. Contact-lens-related microbial keratitis: case report and review. J Optom 2011;4:122-7.

2. Morgan PB, Woods CA, Tranoudis IG, Helland M, Efron N, Jones L, et al. International contact lens prescribing in 2016 Our 16th report in contact lens spectrum outlines the latest trends in contact lens prescribing around the world. Cont Lens Spec 2017;32:30-5.

3. Dart JKG, Stapleton F, Minassian D. Contact lenses and other risk factors in microbial keratitis. Lancet 1991;338:650-3.

4. Brennan NA, Coles ML. Extended wear in perspective. Optom Vis Sci 1997;74:609-23.

5. Morgan PB. Contact lens compliance and reducing the risk of keratitis. Optician 2007;234:20-5.

6. Alfonso E, Mandelbaum S, Fox MJ, Forster RK. Ulcerative keratitis associated with contact lens wear. Am J Ophthalmol 1986;101:429-33.

7. Szczotka FLB, Imamura Y, Chandra JYC, Mukherjee PK, Pearlman E, Ghannoum MA. Increased resistance of contact lens related bacterial biofilms to antimicrobial activity of soft contact lens care solutions. Cornea 2009;28:918-26.

8. Lin L, Kim J, Chen H, Kowalski R, Nizet V. Component analysis of multipurpose contact lens solutions to enhance activity against Pseudomonas aeruginosa and Staphylococcus aureus. Antimicrob Agents Chemother 2016;60:4259-63.

9. Schultz CL, Pezzutti MR, Silor D, White R. Bacterial adhesion measurements on soft contact lenses using a Modified Vortex Device and a Modified Robbins Device. J Ind Microbiol 1995;15: 243-7.

10. Aswad MI, John T, Barza M, Kenyon K, Baum J. Bacterial adherence to extended wear soft contact lenses. Ophthalmology 1990;97:296-302.

11. Meers PD, Chow CK. Bacteriostatic and bactericidal actions of boric acid against bacteria and fungi commonly found in urine. J Clin Pathol 1990;43:484-7.

12. Codling CE, Hann AC, Maillard JY, Russell AD. An investigation into the antimicrobial mechanisms of action of two contact lens biocides using electron microscopy. Cont Lens Anterior Eye 2005;28:163-8.

13. Kamaruzzaman NF, Firdessa R, Good L. Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300. J Antimicrob Chemother 2016;71:1252-9.

14. Ling ML, Ching P, Widitaputra A, Stewart A, Sirijindadirat N, Thu LTA. APSIC guidelines for disinfection and sterilization of instruments in health care facilities. Antimicrob Resist Infect Control 2018;7:25.

Downloads

Published

2018-12-26

How to Cite

1.
ทองวิเศษสุข ธ, สินปรุ เ, หลำใจซื่อ ภ, จำรูญ น. The study of the efficacy of multipurpose solutions to inhibit bacteria on soft contact lens. Dis Control J [Internet]. 2018 Dec. 26 [cited 2024 Mar. 29];44(4):412-21. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/162854

Issue

Section

Original Article