Relationship Between the Detection of HPV E6/E7 mRNA and Cytological Features in Cervical Smears among Female Sex Workers in Chiangmai

  • เจียรนัย ขันติพงศ์ The Office of Diseases and Prevention Control 10 Chiangmai
  • สุรเชษฐ์ อรุโณทอง The Office of Diseases and Prevention Control 10 Chiangmai
  • นิลวรรณ กิตยานุรักษ์ The Office of Diseases and Prevention Control 10 Chiangmai
  • โกวิทย์ นามบุญมี Major of Public Health, School of Health Science, Mae Fah Luang University
  • นิรัชร์ เลิศประเสริฐสุข Faculty of medicine Chiangmai University
Keywords: HPV E6/E7 mRNA test Pap smear, cervical cancer, female sex workers

Abstract

The aim of this study was to evaluate the relationship between the result of HPV E6/E7 mRNA test and Pap smear test in target group sex workers. The subjects were 175 sex workers. Cervical cells were collected using liquid base media. HPV E6/E7 mRNA level in collected cervical cell was tested using Flow cytometer and the cervical cancer cell forming was determined microscopically by pap smear. Among 175 sex workers in the atudy, tTthere were 54 subjects (30.86%) with HPV E6/E7 mRNA test positive and 8 subjects (5.14%) with pap smear test positive. The relation between HPV E6/E7 and pap smear did not show in our study (Fisher exact p-value >0.05).It caused by the sensitivity difference between HPV E6/E7 test and Pap smear test. The sensitivity of HPV E6/E7 mRNA test and pap smear test should be further determined. In in order to evaluate the sensitivity of HPV E6/E7 mRNA test, the cervical cancer incidence among 54 subjects with HPV E6/E7 mRNA positive result should be followed using pap smear.

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Published
2013-06-28
Section
Original Article