Average blood Heme Oxygenase-1 (HO-1) levels in non silica exposure people, Prayao Province
DOI:
https://doi.org/10.14456/dcj.2015.33Keywords:
Heme Oxygenase-1Abstract
This cross sectional study aimed to determine the average of Blood Heme Oxygenase-1 (HO-1) levels on non silica exposed people at Phayao province, Thailand. Forty hundred and ten of non silica exposure cases were randomly recruited from people over 18 years of age and living in the area which is unexposed to silica dust at Phayao province. The results showed the average of Blood HO-1 level in mean on men and women was 26.34 ng/ml and 21.93 ng/ml, respectively. The cases who are 41-50 years old had highest levels of HO-1 level (31.34 ng/ml) and the cases were students had the highest average of HO-1 level (34.47 ng/ml), respectively. Also the difference of median (inter quartile range) of HO-1 levels by sex, age, occupation, smoking, alcohol consumption were not statistically significant (p<0.05). However this study was conducted on normal cases, therefore, the study on silicosis patients must be researched and determine the specificity of HO-1 analysis to improve the early silicosis screening.
Downloads
References
2. อภิสิทธิ มลาสานต์, กาญจนา คงศักดิ์ตระกูล. โรคซิลิโคสิส (silicosis) [อินเทอร์เน็ต]. [สืบค้นเมื่อ 1 ก.ย. 2552]. แหล่งข้อมูล: http://dpc2.ddc. moph.go.th/ option/PSO/pso2 /data/pic/ 31 .doc
3. สำนักโรคจากการประกอบอาชีพและสิ่งแวดล้อม. สถานการณ์โรคจากการประกอบอาชีพและสิ่งแวดล้อม ปี 2550 [อินเทอร์เน็ต]. [สืบค้นเมื่อ 25 ส.ค. 2552]. แหล่งข้อมูล:
http://www.envocc.org/downloads/env_dis_5 OR 3 .doc
4. Fubini B, Hubbard A. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radical Biology and Medicine 2003; 34:1507-16.
5. Saukkonen Katri, Lakkisto Paivi, Kaunisto Mari A, Varpula Marjut, Voipio-PulkkiLiisa-Maria, Varpula Tero, et al. Heme Oxygenase-1 polymorphisms and plasma concentrations in critically 111 patients. Shock 2010;34:558-64.
6. Eom HJ, Choi J. Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B. Toxicol In Vitro 2009;23:1326-32.
7. Wagener FADTG, Volk H-D, Willis D, Abraham NG, Soares MP, Adema GJ, et al. Different faces of the Heme-Heme Oxygenase system in Inflammation. Pharmacological Reviews 2003; 55:551-7.
8. Schipper HM, Chertkow H, Mehindate K, Frankel D, Melmed c, Bergman H. Evaluation of Heme Oxygenase-1 as a systemic biological marker of sporadic AD. Neurology 2000;54:1297-304.
9. Takahashi A, Mori M, Naruto T, Nakajima ร, Miyamae T, Imagawa T, et al. The role of Heme Oxygenase-1 in systemic-onset juvenile idiopathic arthritis. Modern Rheumatology 2009;19:302-8.
10. Exner M, Minar E, Wagner o, Schillinger M. The role of Heme Oxygenase-1 promoter polymorphisms in human disease. Free Radical Biology and Medicine 2004;37:1097-104.
11. Bao W, Rong ร, Zhang M, Yu X, Zhao Y, Xiao X, et al. Plasma Heme Oxygenase-1 concentration in relation to impaired Glucose regulation in a non-Diabetic Chinese population. PLoS ONE 2010;5:e32223.
12. Miyazaki T, Kirino Y, Takeno M, Hama M, Ushihama A, Watanabe R, et al. Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions. International Journal of Hematology 2010;91:229-37.
13. Sato T, Takeno M, HonmaK, Yamauchi H, Saito Y, Sasaki T, et al. Heme Oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury. Am J Respir Crit Care Med 2006;174:906-14.
Downloads
Published
How to Cite
Issue
Section
License
Articles published in the Disease Control Journal are considered as academic work, research or analysis of the personal opinion of the authors, not the opinion of the Thailand Department of Disease Control or editorial team. The authors must be responsible for their articles.
.png){kind=logo}
