Outcomes in patients after repaired tetralogy of Fallot at Maharaj Nakorn Chiang Mai Hospital

Authors

  • Tanetsakulwatana N Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai
  • Kamsap N Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai
  • Jewreungwinyu T Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai
  • Watthanayanont N Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai
  • Chanyutthana S Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai
  • Sethasathien S Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai
  • Silvilairat S Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai

Keywords:

Tetralogy of Fallot, total correction, RV to PA conduit, outcome, mortality

Abstract

Objectives Total correction has been performed in patients with tetralogy of Fallot (TOF) to prevent early death from systemic hypoxemia. However, short- and long-term complications are the major concerns in Thai patients due to insufficient data and loss of follow-up. The aim of this study was to identify the survival rate and predictors for the mortality of patients with TOF after total correction

Methods We included all patients with TOF who had undergone total correction between 1993 and 2019. Medical records were reviewed for patient demographics, operative details and complications. Patients who were diagnosed with double outlet right ventricle (TOF type), lost follow-up or missing data were excluded.

Results A total of 638 patients were included (57.5% male patients, 15.2% TOF with pulmonary atresia, 10.2% genetic abnormalities, 7.2% right ventricle (RV) to pulmonary artery (PA) conduit). The median age at total correction of TOF was 4.4 years (IQR; 2.9-7.4 years). Early and/or late complications developed in 127 patients (20%). The 25-year survival rate was 90%. The crude mortality rate was 7.1%. Multivariate cox regression analysis demonstrated genetic abnormality (HR 3.18 [95%CI 1.61-6.29], p = 0.001) and RV to PA conduit utilization (HR 3.29 [95%CI 1.53-7.10], p = 0.002) were the predictors for mortality.

Conclusions The survival rate was 90% after repaired TOF. The presence of genetic abnormality and RV to PA conduit operation were the predictors of the mortality.

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References

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Published

2021-10-01

How to Cite

1.
N T, N K, T J, N W, S C, S S, S S. Outcomes in patients after repaired tetralogy of Fallot at Maharaj Nakorn Chiang Mai Hospital. Chiang Mai Med J. [Internet]. 2021 Oct. 1 [cited 2022 May 25];60(4):463-74. Available from: https://he01.tci-thaijo.org/index.php/CMMJ-MedCMJ/article/view/253919

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Original Article