Metabolic syndrome in patients with major depressive disorder: A study of one year incidence and associated factors
Keywords:metabolic, depression, incidence, factors
Objective To examine the one year incidence of metabolic syndrome and factors associated with
major depressive disorder.
Methods Patients who had came for treatment of major depressive disorder (MDD) at Maharaj
Nakorn Chiang Mai Hospital were screened using the metabolic syndrome criteria proposed by the
American Heart Association/National Heart, Lung, and Blood Institute (updated ATPIII). Subjects
who did not meet the criteria of metabolic syndrome were screened again at a one year follow-up.
Age, history of atypical antipsychotic medication usage, duration of illness, severity of illness, and
family history of metabolic syndrome were assessed as factors potentially associated with the metabolic syndrome. Data was analyzed using, standard deviation, student t-test, chi-square test, and
Fisher’s exact test and is presented as percentages and means.
Results One hundred and forty subjects were recruited of whom 53 were excluded because they
already had metabolic syndrome. After one year, 77 of the 87 returned for a follow-up visit and were
again screened for metabolic syndrome. The one-year incidence of metabolic syndrome, evaluated
according to ATP III criteria, was 16.9% (13 subjects). Both Baseline triglyceride and HDL levels
were signi fi cantly associated with metabolic syndrome in patients with major depressive disorder
(p ≤0.001). Age, history of atypical antipsychotic medication usage, duration of illness, severity of
illness, and family history of metabolic disorders were not found to be associated with metabolic
Conclusions MDD patients are likely to have or to develop metabolic syndrome. These fi ndings
emphasize the importance of assessing and monitoring metabolic syndrome in MDD patients,
especially patients who have both high triglyceride and HDL levels.