https://he01.tci-thaijo.org/index.php/BJmed <p>Faculty of Medicine, Burapha University, has created the Burapha Journal of Medicine (Bu J Med) for aiming at serving as a medium for disseminating medical academic works in medical science, health sciences, public health, clinical studies, and cutting-edge research. Both Thai and English articles are welcome for publication. It has no policy of charging a publishing fee.</p> <p>ISSN 2350-9996 (Print)</p> <p>ISSN 2822-0242 (Online)</p> คณะแพทยศาสตร์ มหาวิทยาลัยบูรพา en-US Burapha Journal of Medicine 2350-9996 https://he01.tci-thaijo.org/index.php/BJmed/article/view/291448 <p>บูรพาเวชสาร คณะแพทยศาสตร์ มหาวิทยาลัยบูรพา นําเสนอบทความที่ผู้นิพนธ์ส่งมายังกองบรรณาธิการและผ่านการพิจารณากลั่นกรองบทความจากคณะกรรมการผู้ทรงคุณวุฒิ (Peer Review) ก่อนการตีพิมพ์ เพื่อให้เกิดคุณภาพสุงสุด โดยแต่ละบทความวิชาการที่อยู่ในวารสารนี้ต่างผ่านการดำเนินการ ได้ข้อค้นพบ ข้อเสนอแนะ ที่สร้างสรรค์ อันอาจจะส่งผลกระทบต่อบุคคล ครอบครัว ชุมชน สังคมและประเทศชาติ</p> <p>สำหรับบูรพาเวชสารปีที่ 13 ฉบับที่ 2 เดือนพฤษภาคม – สิงหาคม 2569 ประกอบด้วย บทความวิจัยประเภทนิพนธ์ต้นฉบับ 3 บท รายงานผู้ป่วย 4 บท และบทความวิชาการ 1 บท และยังมีการแก้ไขบทความ 1 บท โดยกองบรรณาธิการได้คัดเลือกมานําเสนอ ดังนี้</p> <p>นิพนธ์ต้นฉบับ 3 บท ได้แก่<br /><span style="font-size: 0.875rem;"><br />- การเปรียบเทียบรูปแบบการหยอดยาขยายม่านตาผู้ป่วยเบาหวานด้วยยาหยอดผสมโทรปิคาไมด์และฟีนิลเอฟริน 4 วิธี: การศึกษาทางคลินิกแบบสุ่ม โดยรสพร อัศววรฤทธิ์ (พ.บ.) และ ณัฐวัฒน์ อัศววรฤทธิ์ (พ.บ.)<br /><br /></span><span style="font-size: 0.875rem;">- ประสิทธิผลและการประเมินความคุ้มค่าของคลินิกเบาหวานระยะสงบที่โรงพยาบาลส่งเสริมสุขภาพตำบลตลาดบึง โดย ณัฏฐนิช เชยสมบัติ (พ.บ.)<br /><br /></span><span style="font-size: 0.875rem;">- ปัจจัยที่มีผลต่อการตัดสินใจเข้ารับวัคซีนเอชพีวีของนิสิตเพศชายในมหาวิทยาลัยบูรพา โดยอาจารย์แพทย์จักรพันธุ์ ศิริบริรักษ์ (พ.บ.) และนิสิตแพทย์อีก 7 ราย</span></p> <p>รายงานผู้ป่วย 4 บท ได้แก่<br /><span style="font-size: 0.875rem;">- โรคไซนัสอักเสบจากเชื้อราลุกลามแบบเฉียบพลันชนิด Mucormycosis ในโรงพยาบาลพุทธโสธร โดย ปัทมาวดี ชัยชุมพร (พ.บ.)<br /><br /></span><span style="font-size: 0.875rem;">- โรคเกล็ดเลือดต่ำจากลิ่มเลือดอุดตันในหลอดเลือดขนาดเล็กภายหลังจากการติดเชื้องูสวัดในหญิงชาวไทย : กรณีศึกษา โดย ระวีวรรณ วิฑูรย์ (พ.บ.) อวฤทธิ์ โภคาธิกรณ์ (พ.บ.) สมชาย ยงศิริ (พ.บ.) และ ศิริพร ตั้งจาตุรนต์รัศมี (พ.บ.)<br /><br /></span><span style="font-size: 0.875rem;">- การรักษาโรคเท้าปุกแบบไม่ทราบสาเหตุในเด็กด้วยวิธี Ponseti และการคงสภาพด้วยกายอุปกรณ์เสริมประคองเท้าชนิดรองเท้าสำเร็จรูป Mitchell ในโรงพยาบาลศิริราช: รายงานผู้ป่วย โดย ธนกร ธรรมกรสุขศิริ (กอ.บ.) และ อภินัทธ์ จิรวัฒนาพันธ์ (กอ.บ.)<br /><br /></span><span style="font-size: 0.875rem;">- คอมพาวด์โอดอนโทมาที่สัมพันธ์กับภาวะฟันตัดซี่กลางบนไม่ขึ้นในผู้ป่วยวัยรุ่น: รายงานผู้ป่วย โดย ชวัช ศรีพงษ์ (ท.บ.)</span></p> <p>บทความปริทัศน์หรือการทบทวนวรรณกรรม 1 บท ได้แก่</p> <p>- ฝุ่นละอองแขวนลอยในอากาศและสารละอองชีวภาพเชื้อรา: ปัจจัยร่วมการเกิดโรคระบบทางเดินหายใจ โดย กลุ่มนักเรียนชั้นมัธยมศึกษาปีที่ 5 จำนวน 5 รายควบคุมโดยอาจารย์นิธิศ สมานทอง (ปร.ด.)<br /><br />ลำดับสุดท้าย อาจารย์ปราโมทย์ ธนาศุภกรกุล ผู้นิพนธ์ที่รับผิดชอบขอแก้ไขความผิดพลาดของบทความ เรื่อง แบบสอบถามเพื่อคัดกรองภาวะมวลกล้ามเนื้อน้อยชนิด SARC-F สัมพันธ์กับสมรรถภาพทางกายและความแข็งแรงของกล้ามเนื้อที่ลดลงในประชากรผู้สูงอายุในประเทศไทย</p> <p>ทั้งนี้กองบรรณาธิการ วารสาร บูรพาเวชสาร ขออภัยสำหรับความผิดพลาดในการจัดพิมพ์บทความดังกล่าวข้างต้นและขอให้อ้างอิงบทความที่มีเนื้อหาถูกต้องในเว็บไซด์วารสาร บูรพาเวชสาร เท่านั้น</p> <p> </p> Somjit Prueksaritanond Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 https://he01.tci-thaijo.org/index.php/BJmed/article/view/284930 <p><strong>Introduction</strong>: Acute invasive fungal sinusitis (AIFS) as caused by mucormycosis, is a fulminant and life-threatening condition with a high mortality rate. The disease progresses rapidly to adjacent structures, including the orbits and central nervous system. Early clinical manifestations are often nonspecific, leading to delayed diagnosis and treatment, which results in a substantial increase in patient morbidity and mortality. No previous studies of this condition have been conducted at Buddhasothorn Hospital.<br /><strong><br />Objectives</strong>: To describe the demographic characteristics, clinical presentations, underlying comorbidities, treatment modalities, clinical outcomes, length of hospital stay, and further complications of patients at Buddhasothorn Hospital diagnosed with AIFS, as caused by mucormycosis<br /><br /><strong>Methods</strong>: Data from all cases diagnosed with AIFS due to mucormycosis between 2017 and 2025 at Buddhasothorn Hospital were retrospectively collected. Because of the rarity of the disease, only 6 eligible cases identified from the hospital database were included.<br /><br /><strong>Results</strong>: All cases were male with a mean age of 55 (2.22) years. Diabetes mellitus was the most common underlying comorbidity, presented in 4 of the 6 cases (66.67%). Mucorales infections were isolated and identified in 83.33% of cases. The ethmoid and maxillary sinuses were the most frequently involved of the paranasal sinuses (83.33%). The median interval from symptom onset to initiation of treatment was 10.00 days (range, 6.25–12.25). Ocular symptoms were the most common complaint, occurring in 50% of patients. The most frequently involved extra-sinonasal site was the orbit. All patients received systemic amphotericin B in combination with the surgical debridement of the affected sinuses and adjacent structures. The median duration of antifungal therapy was 52.00 days (range, 41.25–107.00). One patient died (16.67%).<br />No disease recurrence was observed among survivors upon hospital discharge.<br /><br /><strong>Conclusions</strong>: Most cases at Buddhasothorn Hospital of patients with AIFS as caused by mucormycosis had diabetes mellitus as an underlying comorbidity. The most common<br />initial presentation was ocular. The ethmoid and maxillary sinuses were the most frequently affected sites, often extending to the orbits. Despite standard management, including surgical debridement and systemic antifungal therapy, the mortality rate was 16.67%.</p> Pattamavadee Chaichumporn Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 47 59 https://he01.tci-thaijo.org/index.php/BJmed/article/view/288152 <p><strong>Introduction</strong>: Thrombotic thrombocytopenic purpura (TTP) is a rare but fatal disease. Clinical presentations are nonspecific and usually require a skilled physician to detect. Rapid diagnosis and treatment is imperative in clinical practice.<br /><br /><strong>Objective</strong>: To report a case of thrombotic thrombocytopenic purpura in a patient with end stage renal disease.<br /><strong><br />Methods</strong>: Retrospective study that presented the patient’s history, physical examinations, laboratory investigations, imaging, clinical course and treatment. The data is derived from the hospital medical records.<br /><br /><strong>Results</strong>: A 72-year-old Thai female with end stage renal disease on regular hemodialysis, presented with alteration of consciousness and microangiopathic hemolytic anemia. Recent history of herpes zoster skin infection raised a clinical suspicion for herpes meningoencephalitis. However, after adequate treatment, her symptoms deteriorated. Hematology was consulted and a provisional diagnosis of thrombotic thrombocytopenic purpura was made. Plasma exchange was initiated and the patient’s clinical improved after five cycles of plasma exchange with adjunctive corticosteroids. Immunosuppression was prolonged due to refractoriness of TTP. An occult infection of abdominal tuberculosis was later identified as a potential TTP trigger<br />and treated.<br /><br /><strong>Conclusion</strong>: A case study of Thrombotic thrombocytopenic purpura following a herpes zoster infection. Recognizing the condition facilitates appropriate diagnostic testing and early treatment, thereby helping to reduce patient mortality.</p> Raweewan Witoon Arwarit Pocathikorn Somchai Yongsiri Siriporn Tungjaturonrussamee Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 60 73 https://he01.tci-thaijo.org/index.php/BJmed/article/view/283849 <p><strong>Introduction:</strong> Congenital Talipes Equinovarus (CTEV) is a prevalent foot deformity in infants. The currently recognized global standard to care for CTEV is the Ponseti method. This method involves correcting the deformity through serial casting, followed by a phase of maintenance utilizing a foot abduction orthosis, such as the Mitchell brace, which is crucial for preventing relapse.<br /><br /><strong>Objective: </strong>To report the clinical outcomes of treating pediatric patients with CTEV using the Ponseti method and maintenance with the Mitchell brace over a 9-month follow-up period.<br /><br /><strong>Methods:</strong> This study is a case series report on three pediatric patients (aged 1–3 months) treated for CTEV at Siriraj Hospital. Data regarding serial casting, Achilles tenotomy, and use of the Mitchell brace were analyzed. Outcomes were evaluated using the Dimeglio score at the initiation of treatment, and during follow-up appointments at 3, 6, and 9 months. (F1, F2, F3)<br /><br /><strong>Results</strong> Patients required an average of 4–6 casts during their corrective phases. The initial mean Dimeglio score was 9.30 (from a range of 5–12) and decreased to a mean of 7.60 (from a range of 7–9) at the patient’s final follow-up visit. However, a temporary increase in the mean score (mean: 9.30) was observed during the second follow-up, coinciding with each patient’s transition to foot abduction orthosis use. This change highlights the critical importance of consistent brace wear and parental supervision.<br /><br /><strong>Conclusion</strong> This case series of three pediatric patients with congenital talipes equinovarus demonstrates that treatment using the Ponseti method and maintenance with the Mitchell brace leads to a consistent reduction in disease severity over a 9-month follow-up period. Key success factors to prevent relapse include close clinical monitoring and effective parental education on proper brace application.</p> Aphinat Chirawattanaphan Thanakorn Thammakornsuksiri Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 73 80 https://he01.tci-thaijo.org/index.php/BJmed/article/view/285071 <p><strong>Introduction</strong>: Odontoma is a common odontogenic lesion that originates from tooth-forming tissues and is frequently associated with delayed or failed eruption of permanent teeth in children and adolescents. Odontoma can affect oral function, esthetics, and quality of life; therefore, regular dental check-ups, ideally once or twice a year, particularly during childhood when the transition from primary to permanent dentition occurs, are important for preventing complications, and minimizing impacts on long-term dental and maxillofacial development.</p> <p><strong>Objective</strong>: To present the clinical features, radiographic characteristics, diagnosis, and management of compound odontoma, a common odontogenic lesion frequently associated with delayed eruption of permanent teeth in pediatric and adolescent patients.</p> <p><strong>Case Presentation</strong>: A 13-year-old Thai female presented with delayed eruption of the maxillary right central incisor, which should normally erupt at 7–8 years of age. Clinical examination revealed no pain or swelling. Periapical, panoramic and lateral cephalometric radiographs demonstrated multiple tooth-like radiopaque structures surrounded by a narrow radiolucent rim, associated with an impacted right maxillary central incisor. The diagnosis of compound odontoma in the anterior maxilla was made. Surgical enucleation of the lesion was performed, along with the extraction of the embedded tooth. The diagnosis was confirmed by histopathological examination.</p> <p><strong>Conclusion</strong>: A 13-year-old Thai girl presented with an unerupted maxillary right central incisor. She had no history of regular dental check-ups, and no facial abnormalities were observed. The diagnosis was a compound odontoma in the anterior maxilla. The lesion was treated surgically, and no postoperative complications were noted.</p> Chawat Sripong Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 81 92 https://he01.tci-thaijo.org/index.php/BJmed/article/view/283778 <p><strong>Introduction</strong>: Particulate matter (PM) is a primary indicator of air quality and a key determinant of respiratory morbidity and mortality. Fungal bioaerosols, the biological fraction of airborne PM, are emerging as significant yet insufficiently characterized contributors to air pollution and respiratory disorders. Although research on their prevalence and health effects has expanded in recent years, the mechanistic interactions between airborne fungal bioaerosols and PM<br />remain poorly understood.<br /><br /><strong>Objective</strong>: This systematic review was conducted using reputable databases, such as PubMed and Scopus, followed by comprehensive analysis and synthesis of relevant research findings.<br /><br /><strong>Method</strong>: A literature review was conducted using reputable academic databases, including PubMed and Scopus. Relevant studies were systematically analyzed and synthesized.<br /><br /><strong>Results</strong>: Airborne PM and fungal bioaerosols are pollutants that frequently co-occur due to their aerodynamic properties, which facilitate deposition in the respiratory tract and penetration into the alveoli, potentially resulting in synergistic effects upon exposure. Both pollutants can induce oxidative stress, inflammation of the respiratory epithelium, and immune system dysfunction, which are associated with reduced lung function, respiratory symptoms accompanied by infections, and may contribute to carcinogenesis. Advances in monitoring technologies, risk<br />assessment, and air quality management further support the development of effective strategies to reduce exposure to these pollutants.<br /><br /><strong>Conclusion</strong>: The complex interplay between airborne PM and fungal bioaerosols plays a pivotal role in the pathogenesis of respiratory diseases. A deeper mechanistic understanding and the development of innovative exposure reduction and prevention strategies are essential to mitigate their health impacts.</p> Thanathada Promvaree Kittepat Sirisanont Atira Phaychanpheng Intapong Wongtawon Akarin Asawabenjang Nitis Smanthong Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 93 108 https://he01.tci-thaijo.org/index.php/BJmed/article/view/288653 <p><strong>Introduction</strong>: Pupillary dilation is essential for eye<br />examination and surgery, but longstanding diabetes affects autonomic nervous responses. Pupillary dilation in diabetic patients may require repeated mydriatic drops to achieve adequate pupillary size.<br /><br /><strong>Objective</strong>: To determine the most efficient method of a 0.8% tropicamide – 5% phenylephrine combination administration for pupillary dilation in diabetic patients.</p> <p><strong>Methods</strong>: This prospective randomized controlled study compared the efficacy and safety of four mydriatic regimens applied to 84 diabetic patients (168 eyes) scheduled for retinopathy screening. Both eyes of each patient received either one or three mydriatic drops, with one eye randomly assigned to receive antecedent 0.5% tetracaine. Pupillary size, blood pressure, and pulse rate were measured at baseline, and 10-, 20-, and 30-minutes post-administration.</p> <p><strong>Results</strong>: Repeated measures analysis of variance revealed no significant difference in pupillary dilation between each administration group of 42 eyes (<em>p</em>=0.901). Significant interactions were observed for time × sex (<em>p</em>&lt;0.001) and time × age (<em>p</em>&lt;0.001). Women exhibited faster initial dilation at minute 10, while patients over 70 years achieved smaller final diameters. Over 80% of eyes in each group reached the clinical success threshold (≥6 mm) by 30 minutes. Measurement at minute 20 was a highly accurate predictor of final success (area under the receiver operating characteristic curve=0.935). Systemically, blood pressure<br />remained stable (<em>p</em>≥0.140) in all groups, but a pulse rate reduction (5.1 beats/min) only occurred in non-hypertensive cohort (<em>p</em>=0.004). <br /><br /><strong>Conclusions</strong>: A single-drop regimen is equally effective and safe for diabetic patients. Implementing a 5-mm check at minute 20 can efficiently identify slow dilators requiring additional intervention, thereby optimizing outpatient workflow.</p> Rosepon Asawaworarit Nattawat Asawaworarit Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 1 14 https://he01.tci-thaijo.org/index.php/BJmed/article/view/284861 <p><strong>Introduction</strong>: Although the human papillomavirus (HPV) vaccine is highly effective in preventing HPV-related diseases, vaccination uptake among males remains suboptimal.<br /><br /><strong>Objective</strong>: This study aimed to determine the prevalence of intention to receive an HPV vaccination, to assess the level of knowledge regarding HPV infection and the HPV vaccine,<br />and to identify factors associated with HPV vaccination intention among male undergraduate students at Burapha University.<br /><br /><strong>Methods</strong>: A descriptive cross-sectional study was conducted among male undergraduate students at Burapha University. Data were collected from students across 10 faculties, divided into five health-science faculties and five non–health-science faculties. Forty students were recruited from each of the 10 faculties, yielding a total sample of 400 participants. Data were collected using an self-administered online questionnaire.<br /><br /><strong>Results</strong>: The majority of participants (72.54%) reported intentions to receive the HPV vaccine. Among these, 71.53% intended to be vaccinated if the vaccine were provided free of charge, while 27.78% intended to be vaccinated regardless of whether they had to pay for it. Concerning knowledge, most participants demonstrated a high level of knowledge about HPV infection (70.25%) and the HPV vaccine (73.75%). Factors significantly associated with intention to receive HPV vaccination included enrollment in a health-science faculty (aOR = 3.48; 95%CI: 1.86 - 6.52) having a high level of knowledge about the HPV vaccine (aOR = 2.45; 95% CI: 1.19 - 5.06), and having a positive attitude toward HPV vaccination as compared to a moderate attitude (aOR = 4.15; 95% CI: 2.29 - 7.55).</p> <p><strong>Conclusion</strong>: Most male undergraduate students expressed intentions to receive the HPV vaccination, particularly if the vaccine were offered at no cost. Factors associated with HPV<br />vaccination intention included the student’s faculty of study, level of knowledge regarding the HPV vaccine, and attitude toward HPV vaccination.</p> Jukrapun Siriboriruk Thanabodee Thongdeelert Thanaporn Swasdison Thanapol Sawasdee Patarapon Sawasdivong Pakin Ngamswangrungroj Mananya Namsonthi Wisaruta Polampun Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 32 46 https://he01.tci-thaijo.org/index.php/BJmed/article/view/287715 <p><strong>Introduction</strong><strong>: </strong>Type 2 diabetes mellitus is a major public health challenge. Although intensive lifestyle modification can achieve diabetes remission, empirical evidence regarding its clinical efficacy and cost-effectiveness in primary care settings remains limited.</p> <p><strong>Objective</strong><strong>:</strong> To compare reduction levels of HbA1c between patients receiving standard chronic disease care with patients undergoing treatment at a specialized Diabetes Remission clinic, taking into consideration the costs, and cost-effectiveness of both treatments.</p> <p><strong>Methods</strong><strong>: </strong>This retrospective observational medical record review was conducted from March to April 2026 at the Talat Bueng Subdistrict Health Promotion Hospital. 60 newly diagnosed T2DM patients were divided into two groups (n=30 each) consisting of a comparison group and a study group. The comparison group (diagnosed between January 2019 and June 2023) received conventional chronic care, while the study group (diagnosed between July 2023 and December 2024) was treated following a Diabetes Remission clinic model featuring small groups focused on lifestyle modification, de-prescribing and supported by community health volunteers. Therapeutic outcomes were compared at post-diagnosis 1-year intervals. Data were analyzed using descriptive statistics, inferential statistics, and economic evaluation.</p> <p><strong>Results</strong><strong>: </strong>The study group showed a significantly greater mean in HbA1c point reductions (3.30±3.28 percentage points) when measured with the comparison group’s results (1.42±2.32 percentage points; <em>p</em> = 0.013). In the study group, 20 percent of patients achieved diabetes remission, whereas no remissions were observed in the comparison group. Furthermore, the study group demonstrated superior cost-effectiveness, with a CER of 173.09 THB per 1 percentage point of reduced HbA1c levels (as compared to 336.94 THB per percentage point by the comparison group). Additionally, the study group revealed an Incremental Cost-Effectiveness Ratio (ICER) of only 49.63 THB per 1 percentage point of HbA1c reductions.</p> <p><strong>Conclusion</strong><strong>: </strong>The Diabetes Remission clinic, which emphasizes small groups undergoing lifestyle modifications, medication reduction and support from village health volunteers, is more efficient and cost-effective than the standard care model. This approach should be supported in primary care settings to improve long-term health outcomes for diabetic patients.</p> Nuttanich Choeysombat Copyright (c) 2026 Burapha University https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 15 31 https://he01.tci-thaijo.org/index.php/BJmed/article/view/291009 <p><strong>This Correction relates to the following article:<br /><br /></strong>Thanasupakornkul P, Wongsuttilert A, Jaidee W. Punyamana U, Thararam S. SARC-F scores correlated with low physical performance and muscle strength in older Thai adults. Bu J Med. 2018; 5(2). 87-93.</p> <p><a href="https://he01.tci-thaijo.org/index.php/BJmed/article/view/287326/version/74413">URL: https://he01.tci-thaijo.org/index.php/BJmed/article/view/287326/version/74413</a></p> <p>The Editorial Board of the Burapha Journal of Medicine sincerely apologizes for the errors that occurred during the publication of the aforementioned article. Readers are kindly requested to cite and refer exclusively to the corrected version of the article published on the Burapha Journal of Medicine website, Volume 13, Issue 2 (May–August 2026). <br />The details of the errors and corresponding corrections are presented in the attached document on pages 109–112</p> <p> </p> Pramote Thanasupakornkul Alisara Wongsuttilert Wanlop Jaidee Uschara Punyamana Sineenast Thararam Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0 2026-08-31 2026-08-31 13 2 109 112